Welcome at Research Microscopy Center LuciaOptics

We are a non profit organisation in the field of super resolution microscopy

We develop novel super resolution microscopy technologies for simpler, faster and more reliable use in molecular biology, medicine, pharmacology and material sciences

1. time: Meiosis - super resolution image

First super resolution microscopy images of meiosis

Meiosis - for the first time super resolution microscopy has been used to image his most important step of development of individuals.


"Super-resolution imaging reveals structurally distinct periodic patterns of chromatin along pachytene chromosomes",

Prakash et al., 2015 (Cremer-Lab)


Experiments done in mouse cells


Come to our inventors` talks at the FOM:

Monday, March 30 MO-MO-PAR-A Super Resolution I: Novel working principles and methods (I) (Forum 1), 11:00 - 11:40

Three-dimensional spectral precision distance microscopy (SPDM): Principle and methods 11:00 - 11:20
C. Cremer [invited] (Institute of Molecular Biology (IMB), Germany)

Spectral precision distance microscopy (SPDM) of nuclear spatial organization 11:20 - 11:40
C. Cremer [invited] (Institute of Molecular Biology (IMB), Germany)


Tuesday, March 31 TU-AF2-PAR-F Biol. IV: Visualization of dynamics in the cell nucleus (Forum 6), 16:50 - 17:50

Photoconversion of UV excited DNA-binding dyes, and their applications in super-resolution fluorescence microscopy of the cell nucleus 16:50 - 17:10
D. Żurek-Biesiada, P. Waligórski, A.T. Szczurek, U. Birk, Ch. Cremer & J.W. Dobrucki (Jagiellonian University, Poland)

Farfield fluorescence microscopy of nuclear chromatin at molecular optical resolution 17:10 - 17:30
U.J. Birk & C. Cremer (Institute of Molecular Biology (IMB), Germany)

Superresolution imaging of chromatin landscape in meiosis prophase I

17:30 - 17:50
K. Prakash, G. Best, S. Redl, M. Borsos, K. Tachibana-Konwalski, S. Parekh, R. Ketting, U. Birk & C. Cremer (Institute of Molecular Biology (IMB), Mainz Germany, Germany)

Poster P1-B Posters 1-B: Superresolution microscopy I

[P1-B/12] Single molecule localisation microscopy of the distribution of chromatin nanostructures using standard fluorescent probesA.T. Szczurek, K. Prakash, H.-K. Lee, D.J. Żurek-Biesiada, M. Hagmann, G. Best, J.W. Dobrucki, C. Cremer & U. Birk (Institute of Molecular Biology, Germany)

Nobel Prize for Super-Resolved Fluorescence Microscopy

Source: www.nobelprize.org

A former associate of the Cremer Lab, Prof. Dr. Stefan Hell, was awarded the Nobel Prize 2014 in Chemistry for his work on advanced far field light microscopy.

Prof. Hell has published a number of papers on the development and application of advanced optical microscopy techniques together with Prof. Cremer. A particular highlight has been on the development of 4Pi microscopy; the basic concept of this "focused nanoscopy" method was already conceived in the 1970s by the brothers Thomas and Christoph Cremer [C. Cremer, T. Cremer (1978)].

Joint publications Cremer / Hell (1994 - 2014)

Måns Ehrenberg, Member of the Nobel Committee for Chemistry: „This development is expected to revolutionize biology and medicine by, not the least, eventually allowing for realistic, quantitative descriptions at nano-scale resolution of the dynamics of the complex, multidimensional molecular biological processes that define the phenotypes of all life forms.”

Quantitative description at nano-scale resolution in a cell

Quantitative single molecule analysis in a cancer cell - super-resolved fluorescence microscopy with standard fluorescent proteins (C. Cremer), Chromosome (Cooperation C. Cremer/ J. Gall)

18th International Microscopy Congress Prague

Prof. Christoph Cremer invited as plenary speaker



The Czechoslovak Microscopy Society has the pleasure to invite you to Prague in September 2014. The International Microscopy Congress 2014 will provide the biggest international platform for sharing knowledge, exchange of views and experience, and discussion on all aspects of microscopy.

Imaging synaptic contacts by SPDM

Super-resolution light microscpy and nanoscopy imaging


Slot A, 10 September, Small Hall, 14:15 - 14:45

Christoph Cremer: "Superresolution Light Microscopy of Nuclear Genome Organization (invited)

20 Jahre Laborjournal

Vorstoß in atomare Dimensionen

von Christoph Cremer, Mainz/Heidelberg


Die Nanoskopie kann ­inzwischen Objekte auflösen, die nur wenige Nanometer auseinander liegen. Bald dürfte auch diese Grenze fallen.