Nobel Prize for Super-Resolved Fluorescence Microscopy

Source: www.nobelprize.org

A former associate of the Cremer Lab, Prof. Dr. Stefan Hell, was awarded the Nobel Prize 2014 in Chemistry for his work on advanced far field light microscopy.

Prof. Hell has published a number of papers on the development and application of advanced optical microscopy techniques together with Prof. Cremer. A particular highlight has been on the development of 4Pi microscopy; the basic concept of this "focused nanoscopy" method was already conceived in the 1970s by the brothers Thomas and Christoph Cremer [C. Cremer, T. Cremer (1978)].

Joint publications Cremer / Hell (1994 - 2014)

Måns Ehrenberg, Member of the Nobel Committee for Chemistry: „This development is expected to revolutionize biology and medicine by, not the least, eventually allowing for realistic, quantitative descriptions at nano-scale resolution of the dynamics of the complex, multidimensional molecular biological processes that define the phenotypes of all life forms.”

Quantitative description at nano-scale resolution in a cell

Quantitative single molecule analysis in a cancer cell - super-resolved fluorescence microscopy with standard fluorescent proteins (C. Cremer), Chromosome (Cooperation C. Cremer/ J. Gall)

20 Jahre Laborjournal

Vorstoß in atomare Dimensionen

von Christoph Cremer, Mainz/Heidelberg


Die Nanoskopie kann ­inzwischen Objekte auflösen, die nur wenige Nanometer auseinander liegen. Bald dürfte auch diese Grenze fallen.

First super resolution microscopy images of meiosis

Meiosis - for the first time super resolution microscopy has been used to image this most important step of development of individuals.


"Super-resolution imaging reveals structurally distinct periodic patterns of chromatin along pachytene chromosomes",

Prakash et al., 2015 (Cremer-Lab)


Experiments done in mouse cells


Marion and Thomas Cremer receive the Wilhelm Bernhard Medal

The international Society for Histochemistry announces that the 2015 Wilhelm Bernhard Medal goes to Marion and Thomas Cremer for their joint research on nuclear structure and function



Histology award for our board member Thomas Cremer


This is the first molecular insight into the effect ischemia has on the nuclear architecture of cells. On that basis new pharmaceutical drugs against this major widespread diseases can be developed.


Hypoxia (Cellular oxygen insufficiency) occuring in diseases like tumour growth, stroke and cardiac infarction.

Stroke (brain attack) is the second most frequent cause of death after coronary artery disease accounting for 6.4 million deaths (12% of the total).

Cardiac infarction (heart attack), one of the complications of coronary artery disease has with a world-wide incidence rate of 3 - 4 million.


"A transient ischemic environment induces reversible compaction of chromatin"

Kirmes et. al, 2015 (Christoph Cremer & George Reid labs IMB Mainz)


New hope for brain attack and heart attack patients

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